Twenty-four trials had extractable vital sign information (45 treatment arms 1285 patients). Study quality was assessed using the methods of Jadad, and data were synthesized using a random-effects model and weighted mean differences. The primary data extracted were systolic BP (SBP), diastolic BP (DBP), and HR. We searched MEDLINE, EMBASE, and the Cochrane Library for English-language, randomized placebo-controlled trials of oral pseudoephedrine treatment in adults. We assessed whether pseudoephedrine causes clinically meaningful elevations in HR or BP. Oral pseudoephedrine is commonly used to treat symptoms of rhinitis and rhinorrhea, but its effect on blood pressure (BP) and heart rate (HR) remains uncertain. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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